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Education

• Ph.D. University of Zagreb, Croatia

Research Interests

• My research interests are in the broadly defined fields of chemical biology and medicinal chemistry. We use rational synthetic and combinatorial chemistry approaches to synthesize and elucidate structure-activity relationship of novel cyclic peptides and peptidomimetics as versatile platforms for targeted drug delivery or lead compounds for drug discovery. These cyclic peptides and peptidomimetics offer unique advantages, such as high target specificity, structural diversity, and potential for modulation to optimize therapeutic properties, making them promising candidates for overcoming therapeutic challenges where conventional therapies fall short.

Selected Publications

1. R. Rayala, A. Tiller, S.A. Majumder, H.M. Stacy, S.O. Eans, A. Nedovic, J.P. McLaughlin, P. Cudic, Solid-Phase Synthesis of the Bicyclic Peptide OL-CTOP Containing Two Disulfide Bridges, and an Assessment of Its    In Vivo    μ-Opioid Receptor Antagonism after Nasal Administration.    Molecules. (2023) Feb 15;28(4):1822. doi: 10.3390/molecules28041822. PMID: 36838810; PMCID: PMC9963138.
2. Y. Singh, Predrag Cudic, and M. Cudic, Exploring Glycan Binding Specificity of Odorranalectin by Alanine Scanning Library.”    Eur. J. Org. Chem., (2022), e202200302 (1-9), PMID: 36120398; PMCID: PMC9479679
3. K. R. Min, A. Galvis, B. Williams, R. Rayala, P. Cudic, D. Ajdic, Antibacterial and Anti-biofilm Activities of a Novel Synthetic Cyclic Lipopeptide Against Cariogenic Streptococcus mutans UA159,    Antimicrob. Agents Chemother., 61 (2017), e00776-17.
4. R. K. Sajja, P. Cudic, L. Cucullo,    In Vitro    Characterization of Odorranalectin for Peptide-based Drug Delivery Across the Blood-brain Barrier,    BMC Neuroscience, 20 (2019), 22.
5. N. Bionda, R.M. Fleeman, C. De la Fuente-Núñez, M. C. Rodriguez, F. Reffuveille, L. N. Shaw, I. Pastar, S. C. Davis, R. E. Hancock, P. Cudic, Identification of Novel Cyclic Lipopeptides from a Positional Scanning Combinatorial Library with Enhanced Antibacterial and Antibiofilm Activities.    Eur. J. Med. Chem. 108 (2016) 3543-63. PubMed PMID: 26703794.

Patent

P. Cudic, J. McLaughlin, Cyclic peptides, cyclic peptide conjugates and methods of use thereof, (2023), US Patent No. 11,578,100 B2.

Other Information

• American Peptide Society, Member
• American Chemical Society, Member
• National Academy of Inventors, �鶹Ů�� Chapter, Fellow
• International Journal of Peptide Research and Therapeutics, Editorial Board Member
• Current Protein and Peptide Science, Associate Editor
• Protein and Peptide Letters, Regional Editor