Maciej Stawikowski, Ph.D.
Research Associate Professor
Charles E. Schmidt College of Science
Chemistry and Biochemistry
Boca Raton Campus | SE 246
Research Interests
My research focuses on the development of chemical tools and bioactive molecules to study protein–lipid interactions at biological membranes. We design and synthesize lipid-based probes, fluorescent amino acids, peptides, and peptidomimetics to investigate membrane-associated processes, including proteolysis at membrane interfaces. These studies are applied to understanding mechanisms relevant to neuroscience and cancer, with the long-term goal of enabling new therapeutic strategies.
Recent PublicationsÂ
- Alamgir S, Pelletier OB, Thomas D, Rubio V, Stawikowski MJ, Zhang Q. Measuring Membrane Lipid Turnover with the pH-sensitive Fluorescent Lipid Analog ND6. . doi: 10.3791/62717. PMID: 34398155.
- Thomas D, Rubio V, Iragavarapu V, Guzman E, Pelletier OB, Alamgir S, Zhang Q, Stawikowski MJ. Solvatochromic and pH-Sensitive Fluorescent Membrane Probes for Imaging of Live Cells. . doi: 10.1021/acschemneuro.0c00732
- Rubio V., Iragavarapu V.,  Stawikowski M.J. Synthesis and Characterization of ROSA Dye - A Rhodamine B-type Fluorophore, Suitable for Bioconjugation and Fluorescence Studies in Live Cells.  .
- Cudic, P., N. Joshi, D. Sagher, B. T. Williams,  M. J. Stawikowski  and H. Weissbach (2016). "Identification of activators of methionine sulfoxide reductases A and B." Biochem Biophys Res Commun 469(4): 863-867.
- Fields, G. B. and  M. J. Stawikowski  (2016). "Imaging Matrix Metalloproteinase Activity Implicated in Breast Cancer Progression." Methods Mol Biol 1406: 303-329.
- Stawikowski, M. J., R. Stawikowska and G. B. Fields (2015). Collagenolytic Matrix Metalloproteinase Activities toward Peptomeric Triple-Helical Substrates.  .
- Krzywda, S., M. Jaskolski, K. Rolka and  M. J. Stawikowski  (2014). Structure of a proteolytically resistant analogue of (NLys)5SFTI-1 in complex with trypsin: evidence for the direct participation of the Ser214 carbonyl group in serine protease-mediated proteolysis.  .
-  Stawikowski, M. J., B. Aukszi, R. Stawikowska, M. Cudic and G. B. Fields (2014). Glycosylation modulates melanoma cell alpha2beta1 and alpha3beta1 integrin interactions with type IV collagen.  .
Awards and Recognition
- Early Career Reviewer Program Participant at the Center for Scientific Review, NIH, 2016 - present