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Biography

Wen Shen, Ph.D., is a Professor of Biomedical Science.Ìý Dr. Shen’s research Ìýinterests include neural signal processing, ion channel and receptor physiology, and neural and vascular system rearrangement in physiology and pathology. Research in her laboratory is aimed at understanding cellular and molecular mechanisms of synaptic connection, network modulation, and neuroplasticity in the brain and retina, the two systems that are highly correlated in terms of cell types, vasculatures and immune responses and also share characteristics of pathologies. The eye-brain relationship holds benefits for noninvasive approach to the diagnosis of certain retina and brain diseases, including Alzheimer, stroke and age-related vision decline.

Education

• 1999: Ph.D., Physiology and Biophysics, State University of New York at Buffalo

Work History

• 2023-present: Professor, Department of Biomedical Science, College of Medicine, Â鶹ŮÀÉ
• 2010-Present: Adjunct Associate Professor, Center for Complex System and Brain Science, College of Science, Â鶹ŮÀÉ
• 2010-2023: Associate professor, Department of Biomedical Science, College of Medicine, Â鶹ŮÀÉ
• 2007-2010: Associate professor, College of Biomedical Science, Â鶹ŮÀÉ
• 2004-2007: Adjunct Assistant Professor, Department of Physiology and Biophysics, University of Miami Miller School of Medicine
• 2003-2007: Assistant professor, College of Biomedical Science, Â鶹ŮÀÉ
• 1999-2003: Research Assistant Professor, College of Medicine and Biomedical Science, State University of New York at Buffalo

Scholarly Activity

Research Interests

• Neural signal processing, ion channel and receptor physiology
• Synaptic connection, network modulation, and neuroplasticity in healthy and diseased retina and brain
• Neurotrophic factors and neuroprotective agents against neurodegeneration

Selected Peer-Reviewed Publications

• M Nguyen, J Sullivan,Ìý W Shen Ìý(2023). Retinal vascular remodeling in photoreceptor degenerative disease. Exp Eye Res., Sept 234., PMID: 37423458.
• BQ Li, S Gografe, A Munchow, M Lopez-Toledano, ZH Pan andÌý W Shen Ìý(2019) Sex-related differences in the progressive retinal degeneration of the rd10 mouse. Experimental Eye Research, 187: 107773, doi:10.1016/j.exer.2019.107773.
• W Shen, CL Nan, PT Nelson, H Ripps and MM Slaughter (2017) GABA(B) receptor attenuation of GABA(A) currents in neurons of the mammalian central nervous system. Physiological Reports. 5(6) e13129 doi:10.14814/phy2.13129.
• J Yang, CL Nan, H Ripps andÌý W Shen Ìý(2015) Destructive Changes in the Neuronal Structure of the FVB/N Mouse Retina. PLoS ONE 10(6): e0129719. doi:10.1371/journal.pone.0129719. PMCID: PMC4475023.
• Z Jiang, JN Yang, LA Purpura, YF liu, H Ripps andÌý W Shen Ìý(2014) Glycinergic feedback enhances synaptic gain in the distal retina. Journal of Physiology (London), 592 (7) 1479-1492.Ìý PMCID: PMC3979606
• W Shen, LA Purpura, BQ Li, CL Nan, IJ Chang and H Ripps (2013) Regulation of synaptic Transmission at the photoreceptor terminal: A novel role for the cation-chloride cotransporter NKCC1.ÌýÌý Journal of Physiology (London), 591:133-147.Ìý PMCID: PMC3630777.
• S Bulley, YF Liu, H Ripps andÌý W Shen Ìý(2013) Taurine activates delayed rectifier KV channels via a metabotropic pathway in retinal neurons.Ìý Journal of Physiol. (London),591:123-132. PMCID: PMC3630776.Ìý
• M JM Rowan, S Bulley, L Purpura, H Ripps andÌý W Shen Ìý(2013) Taurine regulation of voltage-gated channels in retinal neurons. Advances in Experimental Medicine and Biology. 775:85-99. PMID:23392926.
• H Ripps andÌý W Shen Ìý(2012) Taurine: An exceedingly ‘Essential’ amino acid. Molecular Vision 18:2673-2686. PMCID:PMC3501277.
• M JM Rowan, H Ripps andÌý W Shen Ìý(2010) Fast glutamate uptake via EAAT2 shapes the cone-mediated light offset response in bipolar cells. Journal of Physiology (London), 588(20): 3943-3956. PMCID: PMC3000584.